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Updated: Jun 13, 2026
09:08
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Biosynthesis of polyketides by trans-AT polyketide synthases
1Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Bonn, Germany. joern.piel@uni-bonn.de
Natural Product Reports
|May 14, 2010
Summary
This review covers how trans-AT polyketide synthases create natural products. These versatile enzymes are key to producing important bioactive polyketides.
Area of Science:
- Biochemistry
- Molecular Biology
- Natural Product Synthesis
Background:
- Polyketides are a diverse class of natural products with significant biological activities.
- Polyketide synthases (PKS) are large modular enzymes responsible for their assembly.
- Trans-AT PKS represent a distinct and increasingly recognized subclass of these enzymes.
Purpose of the Study:
- To review the current understanding of the biosynthesis of natural products by trans-AT PKS.
- To highlight the catalytic versatility and significance of this enzyme family.
- To provide a comprehensive overview of recent advancements in the field.
Main Methods:
- Literature review of scientific publications.
- Analysis of biosynthetic pathways and enzymatic mechanisms.
- Compilation of information on known trans-AT PKS and their products.
Main Results:
- Trans-AT PKS are a major group of enzymes involved in bioactive polyketide production.
- These enzymes exhibit remarkable catalytic versatility in generating diverse molecular structures.
- Recent research has elucidated novel pathways and mechanisms for trans-AT PKS.
Conclusions:
- Trans-AT polyketide synthases are crucial for the biosynthesis of numerous bioactive natural products.
- Further research into these enzymes promises to uncover new compounds with therapeutic potential.
- This review synthesizes key findings, underscoring the importance of trans-AT PKS in natural product chemistry.
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