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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
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Immunodeficiency Diseases

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Related Experiment Video

Updated: Jun 13, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

[Immunosuppressive agents in Dermatology].

Aline Lopes Bressan1, Roberto Souto da Silva, Elisa Fontenelle

  • 1Hospital Universitário Pedro Ernesto, Rio de Janeiro, RJ, Brasil.

Anais Brasileiros De Dermatologia
|May 14, 2010
PubMed
Summary
This summary is machine-generated.

Immunosuppressants are drugs that inhibit cell division and reduce inflammation. They are crucial for preventing transplant rejection and treating autoimmune and inflammatory conditions like psoriasis.

Related Experiment Videos

Last Updated: Jun 13, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Area of Science:

  • Pharmacology
  • Immunology
  • Dermatology

Background:

  • Immunosuppressants modulate the immune system by affecting cell division.
  • These drugs possess significant anti-inflammatory properties.
  • Key applications include preventing organ transplant rejection and managing autoimmune diseases.

Purpose of the Study:

  • To describe the most important immunosuppressive drugs.
  • To provide guidance on the proper administration of immunosuppressants.
  • To highlight their role in dermatology, particularly in treating psoriasis.

Main Methods:

  • Literature review of major immunosuppressive agents.
  • Analysis of drug mechanisms of action.
  • Compilation of clinical administration guidelines.

Main Results:

  • Detailed overview of commonly used immunosuppressants.
  • Information on appropriate dosing and monitoring.
  • Emphasis on the therapeutic benefits in inflammatory conditions.

Conclusions:

  • Immunosuppressants are vital for managing immune-related disorders.
  • Proper administration is key to efficacy and safety.
  • Further research can optimize their use in chronic inflammatory diseases.