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[Association between skin tags and insulin resistance]
Andréia de Almeida Tamega1, Adriana Milanezi Pinheiro Aranha, Marcelo Massaki Guiotoku
1Universidade Estadual Paulista, Botucatu, SP, Brasil.
Anais Brasileiros De Dermatologia
|May 14, 2010
Summary
Multiple skin tags on the neck or armpits are strongly linked to insulin resistance. This finding, even after accounting for other risk factors, highlights skin tags as a potential early indicator for insulin resistance.
Area of Science:
- Dermatology
- Endocrinology
- Metabolic Syndrome
Context:
- Skin tags are common dermatological findings.
- Previous research suggests associations between skin tags and conditions like diabetes mellitus, obesity, and insulin resistance.
- Early identification of insulin resistance is crucial for preventive healthcare.
Purpose:
- To investigate the correlation between the presence of skin tags in the neck and axillary regions and the level of insulin resistance.
- To determine if skin tags can serve as a clinical marker for insulin resistance.
Summary:
- A cross-sectional study compared patients with over five skin tags in the neck/axillae (cases) to a control group.
- Insulin resistance was assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index.
- Results showed a significant association between multiple skin tags and elevated HOMA-IR values (OR=1.4), hypertriglyceridemia, and body mass index, independent of other risk factors. Elevated HOMA-IR levels (>3.8) showed a stronger association (OR=7.5).
Impact:
- The study indicates that multiple skin tags are a strong, independent predictor of insulin resistance.
- This finding may facilitate earlier detection and intervention for individuals at risk of metabolic disorders.
- Skin tags could serve as a simple, visible marker for identifying patients who may benefit from further metabolic evaluation.
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