[Diffuse plane idiopathic normolipemic xanthoma with hypersplenism]

Area of Science:

• Dermatology
• Histiocytosis
• Lipid Metabolism

Background:

• Diffuse plane normolipemic xanthoma is a rare histiocytosis.
• Characterized by symmetrical, yellowish-orange plaques on the skin.
• Often associated with xanthelasma and typically affects adults.

Observation:

• An 85-year-old female presented with extensive, asymptomatic yellow-orange plaques.
• The plaques were distributed symmetrically on her trunk and abdomen.
• Symptoms had been present for one year.

Findings:

• Laboratory tests were conducted to assess serum lipids and reticuloendothelial function.
• Results showed no increase in serum lipids.
• No evidence of reticuloendothelial disorders was found.

Implications:

• This case contributes to understanding diffuse plane normolipemic xanthoma in adults.
• Highlights the normolipemic variant of xanthoma, even with extensive cutaneous involvement.
• Emphasizes the importance of clinical presentation in diagnosing xanthoma variants.