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Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Candida dubliniensis does not show phospholipase activity: true or false?
Liliane Alves Scheid1, Débora Alves Nunes Mario, Paulo Guilherme Markus Lopes
1Pharmaceutical Sciences Post-Graduate Program, Universidade Federal de Santa Maria, Santa Maria, RS.
Revista Da Sociedade Brasileira De Medicina Tropical
|May 14, 2010
Summary
Candida albicans from oral candidiasis cases showed phospholipase activity, but Candida dubliniensis did not. Further research is needed to determine if this is a true characteristic or a methodological artifact.
Area of Science:
- Mycology
- Oral Microbiology
- Enzymology
Background:
- Oral candidiasis is often caused by Candida species.
- Phospholipase activity is a virulence factor in some Candida species.
Purpose of the Study:
- To investigate and compare the phospholipase activity of Candida albicans and Candida dubliniensis.
- To assess the role of phospholipase as a potential virulence factor in oral isolates.
Main Methods:
- Phospholipase activity was assessed using the egg yolk agar assay.
- Isolates were obtained from patients diagnosed with oral candidiasis.
Main Results:
- All 48 isolates of Candida albicans exhibited significant phospholipase activity (mean Pz = 0.66).
- None of the 24 isolates of Candida dubliniensis demonstrated detectable phospholipase activity.
Conclusions:
- The absence of phospholipase activity in Candida dubliniensis may be a species-specific trait.
- Methodological factors, such as NaCl concentration, could potentially inhibit Candida dubliniensis phospholipase activity, warranting further investigation.
