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Updated: Jun 13, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Published on: June 2, 2014

Pathophysiology of migraine chronification.

M Aguggia1, M G Saracco

  • 1Neurological Department, Cardinal Massaia Hospital, Via Conte Verde 215, 14100, Asti, Italy. aguggiamarco@tiscali.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 14, 2010
PubMed
Summary

Migraine is a common neurological disorder that can worsen over time. Factors like frequent attacks, obesity, and stress may contribute to its progression.

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Migraine is a prevalent and disabling neurological condition.
  • It is often undiagnosed and undertreated in clinical practice.
  • Migraine is a chronic, recurrent disorder with potentially progressive episodic manifestations.

Purpose of the Study:

  • To explore the progressive nature of migraine.
  • To identify underlying clinical, physiological, and anatomical bases for progression.
  • To investigate mechanisms driving migraine attack generation and activation.

Main Methods:

  • Review of clinical, physiological, and anatomical data related to migraine progression.
  • Analysis of factors contributing to the chronification of migraine.
  • Identification of potentially remediable risk factors.

Main Results:

  • Migraine progression may stem from attack-generating mechanisms or attack-induced activation.
  • Several potentially remediable risk factors for chronification were identified.
  • These include attack frequency, obesity, medication overuse, and caffeine overuse.

Conclusions:

  • Migraine progression has identifiable clinical, physiological, and anatomical underpinnings.
  • Modifiable risk factors can influence the chronification of migraine.
  • Addressing these factors may offer avenues for intervention and management.