Related Experiment Video
Updated: Jun 13, 2026

05:52
Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
Published on: November 4, 2021
[Feed-related selenium poisoning in swine]
M Räber1, T Sydler, U Wolfisberg
1Abteilung Veterinär-Anatomie der Universität Bern. marta.raeber@ita.unibe.ch
Schweizer Archiv Fur Tierheilkunde
|May 14, 2010
Summary
Selenium toxicosis caused severe neurological and dermatological issues in pigs due to contaminated feed. High selenium levels in feed and blood confirmed the diagnosis, highlighting the need for feed quality control.
Area of Science:
- Veterinary Pathology
- Toxicology
- Animal Nutrition
Context:
- A case report detailing selenium toxicosis in a commercial pig-fattening farm.
- Two finisher groups of pigs were affected, exhibiting distinct clinical signs.
- Differential diagnoses, including Foot-and-Mouth Disease and Swine Vesicular Disease, were ruled out serologically.
Purpose:
- To document and analyze a case of selenium toxicosis in pigs.
- To correlate clinical signs, pathological findings, and feed analysis with elevated selenium levels.
- To confirm the diagnosis of selenium toxicosis through toxicological evaluation.
Summary:
- Affected pigs displayed neurological signs (ataxia, paresis) and lameness associated with epidermal ablation of the coronary band and alopecia.
- Post-mortem examination revealed multifocal bilateral symmetric poliomyelomalacia and severe histological changes in the claws.
- Feed analysis showed a 100-fold increase in finishing premix selenium, leading to 20-60 fold increases in finisher feed. Blood selenium levels in affected pigs were 4-10 times higher than normal.
Impact:
- This case highlights the severe clinical and pathological consequences of selenium toxicosis in swine.
- It underscores the critical importance of rigorous feed quality control and selenium level monitoring in animal feed.
- Findings provide valuable insights for veterinarians and nutritionists in diagnosing and preventing similar toxicological events in livestock.
Related Concept Videos
Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Pharmaceutical Poisoning: Treatment Strategies
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Anticholinesterase Agents: Poisoning and Treatment
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
The Periodic Table and Organismal Elements
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

