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Updated: Jun 13, 2026

Quantifying Single Microvessel Permeability in Isolated Blood-perfused Rat Lung Preparation
Published on: June 30, 2014
Effect of carbon monoxide exposure on capillary permeability to albumin and α₂-macroglobulin
H H Parving1, K Ohlsson, H J Buchardt Hansen
1Dept. of Clinical Chemistry A, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, Copenhagen, Denmark.
Abstract:
Carbon monoxide exposure of nine dogs for two to five hours giving an average carboxyhemoglobin concentration of 38 per cent caused an average increase in lymph flow via the thoracic duct of 70 per cent. Lymph flux of albumin (mw 69,000) and α₂-macroglobulin (mw 820,000) showed an average increase of 45 per cent and 90 per cent respectively. These results point to increased capillary permeability of fluid and protein in the splanchnic capillaries. Finally, the investigation suggests that diffusion of α₂-macroglobulin is restricted in the splanchnic capillaries, since a marked difference between the ratio of permeability coefficients for albumin and α₂-macroglobulin (P(alb)/Pα₂ -m=15.4) and the ratio between diffusion coefficients (D(alb)/Dα₂ -m=2.5) were found.
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