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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
Published on: March 14, 2022
Endothelin--biology and disease.
Al-Karim Khimji1, Don C Rockey
1Department of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX 75390-8887, United States.
Cellular Signalling
|May 15, 2010
Summary
Endothelins are key molecules in many bodily functions and diseases. This review covers their cell biology, molecular mechanisms, and roles in conditions like cardiovascular and pulmonary disorders.
Area of Science:
- Biochemistry
- Physiology
- Pathology
Background:
- Endothelins (ETs) are potent vasoactive peptides with critical roles in physiological and pathophysiological processes.
- They influence cardiovascular, pulmonary, and renal systems, and are implicated in development, cancer, and wound healing.
Purpose of the Study:
- To provide a comprehensive review of the cell and molecular biology of the endothelin system.
- To highlight the prominent pathophysiological aspects associated with endothelin dysregulation.
Main Methods:
- Literature review of existing research on endothelin biology and pathology.
- Synthesis of information on endothelin signaling pathways and their involvement in disease.
Main Results:
- Detailed overview of endothelin synthesis, receptors, and signaling cascades.
- Explanation of endothelin's multifaceted roles in various diseases, including cardiovascular disorders, pulmonary hypertension, and cancer.
Conclusions:
- The endothelin system is a crucial regulator of numerous biological processes.
- Understanding endothelin's complex roles is vital for developing therapeutic strategies for related diseases.
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