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Related Experiment Video

Updated: Jun 13, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

Splenectomy leads to a persistent hypercoagulable state after trauma.

Jennifer M Watters¹, Chitra N Sambasivan, Karen Zink

¹Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Science University, Portland, OR, USA. wattersj@ohsu.edu

American Journal of Surgery

|May 15, 2010

Summary

Splenectomy after trauma leads to increased clotting risk, with higher platelet and fibrinogen levels. This hypercoagulability, indicated by coagulation tests, correlated with a higher incidence of deep venous thrombosis in patients who underwent splenectomy.

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Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

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Published on: December 20, 2024

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

Area of Science:

Trauma surgery
Hematology
Coagulation disorders

Background:

Splenectomy is a common surgical procedure for trauma patients with splenic injuries.
The potential for post-splenectomy hypercoagulability remains a significant clinical concern.

Purpose of the Study:

To investigate the impact of splenectomy on coagulation parameters in trauma patients.
To determine if splenectomy is associated with a hypercoagulable state and increased risk of deep venous thrombosis.

Main Methods:

Prospective, nonrandomized, single-center study evaluating coagulation in trauma patients.
Comparison of patients undergoing splenectomy (n=30) versus nonoperative management (n=50).
Analysis of baseline and follow-up coagulation assays, including thromboelastography.

Main Results:

Splenectomy patients were older with higher Injury Severity Scores and longer hospital stays.
Elevated white blood cell and platelet counts, and persistent elevated fibrinogen were observed post-splenectomy.
Thromboelastography indicated faster fibrin cross-linking and enhanced fibrinolysis initially, with greater clot strength at follow-up.
Deep venous thrombosis occurred in 7% of splenectomy patients versus 0% in controls.

Conclusions:

Splenectomy for trauma is associated with persistent hypercoagulability.
Coagulation abnormalities following splenectomy may contribute to an increased risk of deep venous thrombosis.