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Published on: September 12, 2014
Amniotic membrane grafting in patients with epidermolysis bullosa with chronic wounds
Venetia Lo1, Irene Lara-Corrales, Alejandra Stuparich
1Division of Pediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
Background:
Severe forms of epidermolysis bullosa (EB) are characterized by chronic, nonhealing wounds.
Objective:
We sought to evaluate the usefulness of amniotic membranes in patients with EB.
Methods:
A retrospective chart review of patients with EB who were treated with amniotic membranes (two patients, 8 applications) was conducted. The primary outcome measure was number of days to complete healing, and the secondary outcome measures were a qualitative wound score, a visual analog scale score, and potential adverse effects.
Results:
The number of days to detect a significant clinical response, defined as greater than 50% improvement, was 40.3 +/- 21.2 days. The median qualitative wound score was 2 (range 0-5). The mean visual analog scale score at last follow-up was 31.4 +/- 26.8. No adverse events were noted.
Limitations:
Retrospective design, healing assessed by comparing photographs, and partial grafting of some wounds were limitations.
Conclusion:
This proof-of-concept study revealed the potential usefulness of amniotic membrane grafting in promoting healing of chronic wounds in patients with EB.
