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Related Experiment Video

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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

[Acquired copper deficiency myelopathy].

D Videt-Gibou¹, S Belliard, J Rivalan

¹Service de neurologie, CHU Pontchaillou, rue Henri-Le-Guilloux, Rennes, France.

Revue Neurologique

|May 15, 2010

Summary

Acquired copper deficiency can cause neurological issues like myeloneuropathy. Early copper supplementation may improve symptoms, even if delayed, and nephrotic syndrome is a potential complication.

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Area of Science:

Neurology
Hematology
Nephrology

Background:

Acquired copper deficiency presents with known hematological issues and emerging neurological manifestations.
Neurological symptoms include myeloneuropathy, sensory ataxia, and spastic gait, with electrophysiological and MRI findings indicating axonal sensorimotor neuropathy and dorsal column changes.
Causes include gastric surgery, excessive zinc, and malabsorption, though often idiopathic; early intervention is key to preventing deterioration.

Observation:

Two cases of acquired copper deficiency myeloneuropathy are presented, one with concurrent nephrotic syndrome and another with iron overload.
Treatment with copper supplementation resolved biological abnormalities.
One patient experienced significant neurological recovery, including ataxia resolution, after eight months of supplementation.

Findings:

Nephrotic syndrome may be an additional complication of acquired copper deficiency.
Delayed treatment does not invariably lead to poor neurological outcomes.
Copper supplementation can lead to significant neurological improvement.

Implications:

Highlights nephrotic syndrome as a potential consequence of acquired copper deficiency.
Suggests that neurological recovery from copper deficiency myeloneuropathy is possible even with delayed treatment.
Emphasizes the therapeutic potential of copper supplementation for neurological recovery.