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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Published on: November 4, 2010

Delphi project in bronchial asthma. Two stages.

M Fernández-Benítez1, M Ibero Iborra, J Sanz Ortega

  • 1Clínica Universidad de Navarra, Pamplona, Spain. mfernandeb@unav.es

Allergologia Et Immunopathologia
|May 15, 2010
PubMed
Summary

Two Delphi studies on pediatric bronchial asthma revealed improved expert consensus over time. Recent guidelines, like GEMA, significantly increased agreement on diagnosis and treatment, particularly for young children.

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Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Health Services Research

Background:

  • Bronchial asthma management in children presents unique challenges.
  • Previous expert consensus documents showed areas of controversy, particularly regarding early childhood treatment and immunotherapy.
  • Evolving guidelines aim to standardize and improve pediatric asthma care.

Purpose of the Study:

  • To compare two Delphi processes on pediatric bronchial asthma management.
  • To assess changes in expert opinion and consensus over time.
  • To evaluate the impact of updated guidelines on expert agreement.

Main Methods:

  • Two Delphi studies were conducted: one based on a consensus document from five associations, and a more recent one using GEMA (Spanish Guidelines on the Management of Asthma).
  • A descriptive study compared the Delphi processes, analyzing consensus levels on specific questions.
  • Questionnaires were administered to expert panels to gauge agreement on diagnosis and treatment strategies.

Main Results:

  • The initial consensus document faced significant controversy regarding treatment for children under three and immunotherapy for allergic asthma.
  • The Delphi process using GEMA demonstrated a substantial increase in expert consensus, reaching 87.5% agreement in the first round.
  • Specifically for pediatric diagnosis and treatment, the GEMA-based Delphi achieved full consensus in the first round, with only minor disagreements in the second round (8.92%).

Conclusions:

  • Clinical guidelines and consensus documents, such as GEMA, can effectively modify expert behavior regarding asthma diagnosis and treatment.
  • The Delphi methodology, when applied to updated guidelines, enhances expert agreement and potentially improves patient care.
  • There has been a measurable improvement in expert consensus on pediatric bronchial asthma management following the implementation of newer guidelines.