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Updated: Jun 13, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
[Normal tissue tolerance to external beam radiation therapy: kidney]
1Service d'Oncologie-Radiothérapie, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, 4 rue de la Chine, 75020 Paris, France.
Summary
Kidney radiation toxicity is often underreported due to non-specific symptoms appearing years later. This review details radiation effects on kidneys and provides clinical dose recommendations.
Area of Science:
- Radiation oncology
- Nephrology
- Medical physics
Background:
- Kidney radiation toxicity is an under-recognized clinical issue.
- Delayed, non-specific symptoms can mask radiation-induced kidney damage.
- Significant morbidity and mortality can arise from moderate radiation doses.
Purpose of the Study:
- To review existing data on kidney tolerance to radiation therapy.
- To describe early and late radiation-induced renal effects.
- To propose dose recommendations for clinical practice.
Main Methods:
- Literature review of radiation effects on the kidney.
- Analysis of clinical symptomatology and latency periods.
- Synthesis of data to establish tolerance levels.
Main Results:
- Kidney damage from radiation is often delayed and presents with non-specific symptoms.
- Late effects can lead to substantial patient morbidity and mortality.
- Data suggests specific dose thresholds for renal tolerance.
Conclusions:
- Awareness of potential late renal effects is crucial in radiation oncology.
- Establishing clear dose limits is essential for minimizing radiation-induced kidney damage.
- Further research may refine clinical guidelines for kidney Sparing radiation therapy.
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