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Updated: Jun 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Special considerations in pediatric asthma
Annabelle Quizon1, Andrew A Colin
1University of Miami-Miller School of Medicine, Department of Pediatrics, Division of Pediatric Pulmonology, 1st Floor, Batchelor Children's Research Institute, 1580 NW 10th Avenue, Miami, FL 33136, United States. aquizon@med.miami.edu
Insights
Childhood asthma management focuses on effective interventions and safe controller medications. Inhaled corticosteroids (ICS) are effective but do not alter asthma progression; lowest effective doses minimize risks.
Area of Science:
- Pediatric Pulmonology
- Allergy and Immunology
- Clinical Pharmacology
Background:
- Asthma is a prevalent chronic childhood illness.
- Interventions aim to alter disease course and address medication safety concerns.
- Inhaled corticosteroids (ICS) are common controller medications.
Purpose of the Study:
- Review the efficacy and safety of ICS in children.
- Explore the use of as-needed ICS for risk reduction in mild persistent asthma.
- Discuss updated asthma management guidelines and other interventions.
Main Methods:
- Literature review of recent studies on ICS use in children.
- Analysis of safety and efficacy data for inhaled corticosteroids.
- Examination of National Institutes of Health (NIH) asthma guidelines (2007).
Main Results:
- ICS are effective for symptom control but do not alter long-term asthma progression in very young children.
- Titrating ICS to the lowest effective dose is key for risk reduction.
- Other strategies include allergen avoidance, obesity management, and appropriate inhaler devices.
Conclusions:
- Optimizing ICS dosage and considering alternative strategies are crucial for managing childhood asthma.
- Updated guidelines emphasize a comprehensive approach beyond medication alone.
- Environmental factors and patient adherence are vital for effective asthma control.
Abstract:
Asthma is the most common chronic illness in childhood with challenges that revolve around interventions that can potentially alter the course of the disease and concerns regarding the safety of regular use of controller medications. Recent studies suggest that the use of inhaled corticosteroids in very young children with frequent wheezing episodes and at high risk for asthma, while effective, does not alter the eventual progression to asthma. As a controller medication, the safety of inhaled corticosteroids as regards efficacy and risk are reviewed. The use of as-needed ICS as a strategy to reduce risk of adverse events can be explored in children with mild persistent asthma. The key to risk reduction is to titrate the dose of steroids to the lowest dose needed to achieve asthma control. Aside from inhaled corticosteroids, other controller medications are described within the framework of the updated asthma guidelines released by the NIH-National Asthma Education and Prevention Program in 2007. Other interventions that may attenuate asthma risk and severity include environmental measures towards allergen avoidance and attention to the increasing prevalence of obesity. The use of age-appropriate delivery systems for inhaled medications is also important for asthma control.
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