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Changes in peripheral nerve function with long-term hemofiltration treatment.

H Beckmann, C Ossenkop, E Quellhorst

    Journal of Dialysis
    |January 1, 1977
    PubMed
    Summary
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    Hemofiltration treatment improved peripheral nerve function in chronic renal failure patients, enhancing vibratory perception and nerve conduction velocity. Vibratory perception threshold measurements are effective for diagnosing nephrogenic polyneuropathy.

    Area of Science:

    • Nephrology
    • Neurology
    • Medical Technology

    Background:

    • Chronic renal failure (CRF) often leads to nephrogenic polyneuropathy, affecting peripheral nerve function.
    • Standard treatments for CRF may not fully address associated neurological complications.

    Purpose of the Study:

    • To evaluate the impact of long-term hemofiltration on peripheral nerve function in CRF patients.
    • To assess the efficacy of vibratory perception threshold (VPT) measurements in diagnosing nephrogenic polyneuropathy.

    Main Methods:

    • Longitudinal study analyzing peripheral nerve function in CRF patients undergoing hemofiltration for 1.5-2 years.
    • Quantitative measurements included vibratory perception threshold and nerve conduction velocity.
    • VPT measured before and after hemofiltration sessions in a subset of patients.

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    Main Results:

    • Hemofiltration treatment led to observable improvements in peripheral nerve function, despite elevated creatinine and BUN levels.
    • Vibratory perception and nerve conduction velocity did not normalize but showed significant improvement post-treatment.
    • VPT measurements directly after hemofiltration demonstrated enhanced vibratory perception compared to baseline values.

    Conclusions:

    • Long-term hemofiltration can positively influence peripheral nerve function in patients with chronic renal failure.
    • Vibratory perception threshold measurement is a reliable and advantageous method for routine diagnosis of nephrogenic polyneuropathy.