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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
The population dynamics and control of tuberculosis
Christopher Dye1, Brian G Williams
1World Health Organization, CH1211 Geneva 27, Switzerland. dyec@who.int
Science (New York, N.Y.)
|May 15, 2010
Summary
Tuberculosis (TB) control has treated millions, yet new cases rise. Early diagnosis and treatment are key to interrupting transmission and controlling this persistent global health challenge.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Tuberculosis (TB) control strategies have treated over 36 million patients since 1995.
- Despite control efforts, global incidence of new TB cases is increasing, nearing 10 million in 2010.
- The complex relationship between Mycobacterium tuberculosis and its human host contributes to TB persistence.
Purpose of the Study:
- To review the evolving host-pathogen relationship in tuberculosis.
- To examine factors contributing to the persistence of TB globally.
- To identify priorities for effective TB control.
Main Methods:
- Review of existing literature on tuberculosis epidemiology and control.
- Analysis of the host-pathogen dynamics of Mycobacterium tuberculosis.
- Examination of social, institutional, and epidemiological factors influencing TB control.
Main Results:
- While interventions exist to reduce susceptibility and a vaccine could aid prevention, these are not the sole solutions.
- Early diagnosis and prompt drug treatment are critical for interrupting TB transmission.
- The success of any TB control technology is heavily dependent on the context of its application.
Conclusions:
- Interrupting TB transmission through early diagnosis and treatment remains the highest priority.
- Technological advancements in TB control must consider the socio-institutional and epidemiological environment.
- Addressing the persistence of TB requires a multifaceted approach beyond just medical interventions.
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