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Updated: Jun 13, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Relationship between urine bisphenol-A level and declining male sexual function.

De-Kun Li¹, Zhijun Zhou, Maohua Miao

¹Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. dkl@dor.kaiser.org

Journal of Andrology

|May 15, 2010

Summary

Bisphenol-A (BPA) exposure is linked to male sexual dysfunction in humans. Higher BPA levels in urine correlate with decreased sexual desire, erectile difficulties, and lower satisfaction.

Related Experiment Videos

Last Updated: Jun 13, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Area of Science:

Environmental Health
Reproductive Toxicology
Human Health Risk Assessment

Background:

Bisphenol-A (BPA) is a widespread environmental chemical with known adverse effects on the male reproductive system in animal models.
Human population studies on BPA's reproductive health impact are limited, despite its ubiquitous presence in the human body.
Understanding BPA's effects in humans is crucial due to potential public health implications.

Purpose of the Study:

To investigate the association between urinary bisphenol-A (BPA) levels and male sexual function in a human population.
To quantify the relationship between BPA exposure and various domains of male sexual health.

Main Methods:

A study involving 427 male workers from high-exposure regions.
Urine samples analyzed for BPA concentration using high-performance liquid chromatography.
Male sexual function assessed using validated sexual function inventories across 4 domains and 7 indices.
Linear regression analysis employed to control for confounders.

Main Results:

Increasing urinary BPA levels showed a significant negative linear correlation with male sexual function across all 7 measured indices.
Higher BPA levels were associated with decreased sexual desire (P < .001), erectile dysfunction (P < .001), reduced ejaculation strength (P < .001), and lower sexual satisfaction (P < .01).
A similar negative trend was observed in a smaller subgroup with environmental BPA exposure only.

Conclusions:

This study demonstrates a correlation between biological measures of BPA exposure (urinary BPA) and declining male sexual function in humans.
Findings suggest BPA may adversely affect male reproductive health in the general population.
The results highlight the public health significance of widespread BPA exposure and its potential impact on male sexual health.