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Updated: Jun 13, 2026

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
Published on: April 21, 2023
The relationship between thyroid nodules and uterine fibroids
Min-Hee Kim1, Ye Ree Park, Dong-Jun Lim
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seocho-Gu, Seoul, Korea.
Uterine fibroids are significantly associated with thyroid nodules in women, particularly premenopausal individuals. Estrogen may play a key role in the development of both conditions.
Area of Science:
- Endocrinology
- Gynecology
- Oncology
Background:
- Estrogen's role in thyroid nodule formation is suggested by previous studies.
- Women with uterine fibroids, influenced by estrogen, show increased thyroid nodule incidence.
Purpose of the Study:
- To identify the relationship between uterine fibroids and thyroid nodules.
- To determine factors influencing thyroid nodule occurrence.
Main Methods:
- Retrospective review of 925 participants' health check-up records (2005-2008).
- Evaluation of clinical variables including nodule characteristics, fibroid presence, menopausal status, BMI, and hormone levels.
- Statistical analysis including univariate and multivariate logistic regression.
Main Results:
- A significant association (P=0.010) was found between uterine fibroids and thyroid nodules, with a stronger link in premenopausal women (P=0.001).
- Higher systemic estradiol (E2) levels showed an inverse correlation with thyroid nodules in premenopausal women (P=0.024).
- Older age and presence of uterine fibroids were independent factors for thyroid nodules.
Conclusions:
- Uterine fibroids are definitively associated with thyroid nodules in women.
- Estrogen likely plays a pivotal role in the development of both uterine fibroids and thyroid nodules.
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