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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
Seronegative HIV-1 infection: a review of the literature
Adam M Spivak1, Emily R M Sydnor, Joel N Blankson
1Johns Hopkins School of Medicine, Division of Infectious Diseases, Baltimore, Maryland 21287, USA.
Abstract:
HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.
