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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Hepatitis E virus in HIV-infected patients
Christophe Renou1, Alain Lafeuillade, Jean-François Cadranel
1Hôpital de jour, Centre Hospitalier, Hyères, France. crenou@ch-hyeres.fr
AIDS (London, England)
|May 15, 2010
Summary
Hepatitis E virus (HEV) infection is a risk for HIV-infected patients in France, with higher prevalence in the south. This study found no chronic HEV infections in this population.
Area of Science:
- Virology
- Infectious Diseases
- Hepatology
Background:
- Hepatitis E virus (HEV) is an emerging pathogen with increasing autochthonous cases in France.
- Chronic HEV infection is documented in immunosuppressed individuals.
- The risk of HEV chronicity in HIV-infected patients remains understudied.
Purpose of the Study:
- To determine the sero-virological prevalence of HEV in HIV-infected patients in France.
- To investigate geographical variations in HEV prevalence within France.
Main Methods:
- A cross-sectional study was conducted on 245 HIV-infected patients from southern and northern France.
- Sera were tested for anti-HEV IgG and IgM antibodies.
- HEV RNA was amplified, and IgG avidity was assessed.
Main Results:
- HEV seroprevalence was significantly higher in southern (12/133, 9%) compared to northern patients (3%, P=0.04).
- Acute HEV infection markers (IgM, RNA, cytolysis) were detected in three southern patients.
- No significant difference in biochemical liver abnormalities was observed between the north and south.
Conclusions:
- HIV-infected patients in France face a risk of HEV infection, exhibiting a north-to-south serological gradient.
- This study did not detect any cases of chronic HEV infection among the studied HIV-infected patients.
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