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Related Experiment Video

Updated: May 26, 2026

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation
22:02

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation

Published on: June 30, 2012

MicroRNA expression in the embryonic mouse inner ear.

Xian-Ren Wang1, Xue-Mei Zhang, Jing Zhen

  • 1Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China.

Neuroreport
|May 15, 2010
PubMed
Summary

MicroRNAs (miRNAs) are widely expressed in the developing mouse inner ear. Their expression increases as sensory hair cells differentiate, suggesting a crucial role in inner ear development.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA (miRNA) expression is known in the postnatal mouse inner ear.
  • However, miRNA expression during inner ear embryogenesis, particularly in the sensory epithelium, remains poorly understood.

Purpose of the Study:

  • To investigate miRNA expression patterns in the developing mouse inner ear at embryonic days E13.5 and E16.5.
  • To identify specific miRNAs involved in inner ear development and neuronal differentiation.

Main Methods:

  • Microarray analysis
  • Quantitative real-time-PCR (qRT-PCR)
  • In-situ hybridization

Main Results:

  • Several miRNAs, including miRNA-182, miRNA-140, and miRNA-200c, exhibited distinct temporal and spatial expression patterns.

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Last Updated: May 26, 2026

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation
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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

  • MiRNA-194 was detected in the spiral ganglia, suggesting a potential role in mouse inner ear neuronal differentiation, similar to its function in zebrafish intestinal epithelium.
  • The study observed a broad expression of miRNAs in the developing inner ear, with an increase in miRNA species as hair cells differentiate.

    • Conclusions:

    • MicroRNAs are widely expressed during inner ear embryogenesis.
    • The recruitment of additional miRNAs correlates with hair cell differentiation.
    • These findings highlight the significant developmental role of miRNAs in the inner ear.