Related Experiment Video
Updated: Jun 13, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
Atopic dermatitis in children: what to do when nothing works
1Department of Dermatology, Berufsgenossenschaftliches Unfallkrankenhaus Hamburg Hamburg, Germany.
Pediatric atopic eczema treatment requires regular emollient and anti-inflammatory use. If treatment fails, focus on patient education and environmental trigger elimination before considering systemic immunosuppression.
Area of Science:
- Dermatology
- Pediatrics
- Allergology
Background:
- Atopic eczema is a common childhood skin condition.
- Standard management includes emollients, topical anti-inflammatories, education, and trigger avoidance.
- Treatment failure can be distressing for families.
Purpose of the Study:
- To review common causes of treatment failure in childhood atopic eczema.
- To provide strategies for managing treatment-resistant cases.
- To emphasize the importance of adherence and environmental control.
Main Methods:
- Literature review of treatment strategies for atopic eczema.
- Analysis of factors contributing to treatment non-response.
- Discussion of alternative and advanced treatment options.
Main Results:
- Non-compliance and unaddressed environmental triggers are primary reasons for treatment failure.
- Parental education and reassurance are crucial for successful management.
- Systemic immunosuppression is reserved for severe, refractory cases after exhausting other options.
Conclusions:
- Optimizing adherence and eliminating triggers are key to successful atopic eczema management.
- A structured educational approach empowers parents to manage the condition effectively.
- Systemic therapies should be a last resort in pediatric atopic eczema treatment.
Related Concept Videos
Acne Infection
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Allergic Reactions

