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Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure
M J Richard1, J Arnaud, C Jurkovitz
1Laboratoire de Biochimie C, CHRUG, Grenoble, France.
Nephron
|January 1, 1991
Summary
Patients on hemodialysis show lower selenium and glutathione peroxidase levels, indicating impaired antioxidant defense. This may contribute to cellular damage during dialysis treatment.
Area of Science:
- Biochemistry
- Nephrology
- Clinical Nutrition
Background:
- Maintenance hemodialysis (HD) patients often exhibit altered trace element status.
- Antioxidant enzymes play a crucial role in mitigating oxidative stress.
Purpose of the Study:
- To investigate plasma selenium (Se), zinc (Zn), and copper (Cu) levels.
- To assess the activity of antioxidant metalloenzymes, glutathione peroxidase (GPX) and superoxide dismutase (SOD), in HD patients.
Main Methods:
- Studied 17 HD patients, 14 uremic patients, and 14 healthy controls.
- Measured plasma Se, Zn, Cu concentrations.
- Assessed erythrocyte GPX and SOD activities, and plasma malondialdehyde (MDA) and catalase levels.
Main Results:
- HD patients had significantly lower plasma Se and erythrocyte GPX compared to controls.
- Correlations observed between decreased plasma Se and GPX, and between decreased plasma Zn/Cu and erythrocyte SOD.
- Plasma MDA levels were elevated, and catalase activity increased in HD patients.
Conclusions:
- Defective antioxidant activity, particularly involving selenium and GPX, is present in hemodialysis patients.
- This impairment may contribute to increased peroxidative damage to cells during dialysis.