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Related Concept Videos

Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Related Experiment Video

Updated: Jun 13, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Neonatal jaundice.

J D Matthew

    Canadian Family Physician Medecin De Famille Canadien
    |May 15, 2010
    PubMed
    Summary
    This summary is machine-generated.

    This article discusses infant jaundice, covering bilirubin metabolism, causes, and modern treatments for newborns. It provides guidance for healthcare professionals managing jaundiced infants in the nursery.

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    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

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    Related Experiment Videos

    Last Updated: Jun 13, 2026

    Isolation of Neonatal Extrahepatic Cholangiocytes
    07:54

    Isolation of Neonatal Extrahepatic Cholangiocytes

    Published on: June 5, 2014

    Biochemical Measurement of Neonatal Hypoxia
    13:13

    Biochemical Measurement of Neonatal Hypoxia

    Published on: August 24, 2011

    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
    07:27

    How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

    Published on: August 19, 2020

    Area of Science:

    • Neonatology
    • Pediatric Gastroenterology
    • Biochemistry

    Background:

    • Neonatal jaundice is a common clinical finding.
    • Understanding bilirubin metabolism is crucial for diagnosis and management.
    • Early identification of causes and sequelae prevents complications.

    Purpose of the Study:

    • To review the metabolism and fate of bilirubin in neonates.
    • To outline diagnostic considerations for jaundiced infants.
    • To discuss modern treatment strategies for neonatal hyperbilirubinemia.

    Main Methods:

    • Literature review on bilirubin metabolism.
    • Clinical case discussion framework for jaundiced neonates.
    • Overview of current therapeutic interventions.

    Main Results:

    • Bilirubin is processed through specific metabolic pathways.
    • Various etiologies contribute to neonatal jaundice.
    • Effective treatment modalities exist to manage hyperbilirubinemia.

    Conclusions:

    • A systematic approach is essential for evaluating jaundiced newborns.
    • Timely and appropriate treatment can mitigate potential long-term effects.
    • Knowledge of bilirubin metabolism aids in clinical decision-making.