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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 13, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Malignant melanoma.

D S Birdsell

    Canadian Family Physician Medecin De Famille Canadien
    |May 15, 2010
    PubMed
    Summary

    Superficial malignant melanoma offers good surgical cure chances. Prophylactic excision of junctional nevi on palms, soles, and genitalia is recommended due to their origin from these precursors.

    Area of Science:

    • Dermatology
    • Surgical Oncology

    Background:

    • Malignant melanoma diagnosis does not always indicate a poor prognosis.
    • Superficial tumors have a higher likelihood of successful surgical removal.
    • Most malignant melanomas originate from junctional nevi.

    Purpose of the Study:

    • To highlight the curability of superficial malignant melanoma.
    • To recommend prophylactic excision of specific nevi.
    • To outline current treatment strategies for malignant melanoma.

    Main Methods:

    • Review of malignant melanoma characteristics and prognosis.
    • Identification of precursor lesions (junctional nevi).
    • Description of surgical techniques including wide excision and skin grafting.
    • Mention of adjuvant therapies like chemotherapy and immunotherapy for advanced disease.

    More Related Videos

    Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
    05:46

    Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

    Published on: December 2, 2022

    Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
    06:09

    Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

    Published on: June 7, 2019

    Related Experiment Videos

    Last Updated: Jun 13, 2026

    A 3D Organotypic Melanoma Spheroid Skin Model
    08:49

    A 3D Organotypic Melanoma Spheroid Skin Model

    Published on: May 18, 2018

    Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
    05:46

    Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

    Published on: December 2, 2022

    Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
    06:09

    Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

    Published on: June 7, 2019

    Main Results:

    • Superficial malignant melanoma has a favorable prognosis with surgical intervention.
    • Junctional nevi, particularly on the palms, soles, and genitalia, are precursors and warrant prophylactic excision.
    • Standard treatment involves wide excision and reconstruction, with systemic therapies for disseminated cases.

    Conclusions:

    • Early diagnosis and surgical treatment of superficial malignant melanoma lead to good outcomes.
    • Prophylactic removal of high-risk nevi is a key preventive measure.
    • Multimodal treatment approaches are essential for managing malignant melanoma, especially in advanced stages.