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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
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Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Updated: Jun 13, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Polyneuropathy.

A H Rajput

    Canadian Family Physician Medecin De Famille Canadien
    |May 15, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Polyneuropathy involves widespread peripheral nerve damage, causing sensory loss and muscle weakness. A clinical approach helps diagnose this condition by identifying its diverse causes.

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    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

    Published on: February 13, 2018

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    Last Updated: Jun 13, 2026

    Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
    08:56

    Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

    Published on: October 7, 2021

    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
    09:39

    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

    Published on: February 13, 2018

    Area of Science:

    • Neurology
    • Clinical Medicine

    Background:

    • Polyneuropathy presents as simultaneous, bilateral, and symmetrical peripheral nerve involvement.
    • Key clinical signs include sensory disturbances ('glove and stocking' pattern), distal muscle weakness, and diminished reflexes.

    Purpose of the Study:

    • To present a diagnostic scheme for polyneuropathy based on clinical features.
    • To aid in narrowing down the differential diagnoses for polyneuropathy.

    Main Methods:

    • Clinical feature analysis.
    • Development of a diagnostic pathway.

    Main Results:

    • Common polyneuropathy causes include alcohol-induced, Guillain-Barre syndrome, and diabetes mellitus.
    • A systematic clinical approach can effectively differentiate potential causes.

    Conclusions:

    • Polyneuropathy diagnosis requires a structured approach due to its multifactorial etiology.
    • Clinical assessment is crucial for guiding further investigations in polyneuropathy cases.