Related Experiment Video
Updated: Jun 13, 2026

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
Published on: December 18, 2014
Use and abuse of propranolol
Abstract:
Propranolol has been available to clinical medicine for over a decade. It was used initially in the treatment of tachyarrhythmias and angina pectoris but now has much more widespread application. Recently the drug is being used more frequently in the treatment of hypertension, and its indications are discussed.The metabolism and clearance in the liver has major effects on the serum level. With improved knowledge of the properties and adverse effects of this potent agent, it is now possible to apply better patient selection.
Related Concept Videos
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
Antihypertensive Drugs: Types of β-Blockers
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Adrenergic Antagonists: Chemistry and Classification of β-Receptor Blockers
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...