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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
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Nova scotia fetal risk project.

M Hebb, I Macpherson, D Cudmore

    Canadian Family Physician Medecin De Famille Canadien
    |May 15, 2010
    PubMed
    Summary

    Family physicians in Nova Scotia used a fetal risk scoring system to assess 17,270 patients. High-risk scores correlated with increased stillbirths and neonatal deaths, with no apparent benefit for participants versus non-participants.

    Area of Science:

    • Obstetrics and Gynecology
    • Family Medicine
    • Perinatal Health

    Background:

    • Family physicians historically provided obstetrical care.
    • Assessing fetal risk is crucial for improving perinatal outcomes.
    • The Goodwin, Dunne and Thomas fetal risk scoring system was utilized.

    Purpose of the Study:

    • To evaluate the effectiveness of a fetal risk scoring system in identifying high-risk pregnancies.
    • To determine if participation in a fetal risk project improved patient outcomes.
    • To analyze the correlation between risk scores and stillbirth/neonatal death rates.

    Main Methods:

    • A retrospective study involving 17,270 patients from 1971-1975 in Nova Scotia.
    • Utilized the Goodwin, Dunne and Thomas fetal risk scoring system.

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  • Compared outcomes between physicians who participated and those who did not.
  • Main Results:

    • Patients with higher risk scores (4-10 on the full system) accounted for 60% of stillbirths and 68% of neonatal deaths.
    • Using a modified scoring system (3-6 on non-gestational portion) still showed significant risk correlation.
    • No demonstrable difference in outcomes between patients of participating and non-participating physicians was observed.

    Conclusions:

    • The fetal risk scoring system identified a significant proportion of adverse perinatal outcomes.
    • The effectiveness of the scoring system and the project's impact on outcomes require further investigation.
    • Physician participation in the fetal risk project did not appear to improve patient outcomes during the study period.