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Related Concept Videos

Relative Motion Analysis - Acceleration01:10

Relative Motion Analysis - Acceleration

A slider-crank mechanism converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider. The movement of the slider-crank is an example of general plane motion as the fluctuating angle between the crank and the connecting rod. Consider a segment AB where point A is at the end of the slider and point B is on the diametrically opposite end to point A, on a crack. The variance in...
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Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface.
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Cucurbituril slippage: translation is a complex motion.

Xiaoxi Ling1, E Loic Samuel, Devin L Patchell

  • 1Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, USA.

Organic Letters
|May 18, 2010
PubMed
Summary

Guest molecule shape significantly impacts cucurbit[6]uril (CB[6]) supramolecular assembly dynamics. In silico studies reveal a threading mechanism involving amine deprotonation, tunneling, and reprotonation for CB[6] slippage along polyaminated axles.

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Area of Science:

  • Supramolecular Chemistry
  • Computational Chemistry

Background:

  • Cucurbit[6]urils (CB[6]) are macrocyclic hosts with unique cavity structures.
  • The dynamic behavior of CB[6] interactions with guest molecules is crucial for molecular machine applications.

Purpose of the Study:

  • To investigate the influence of guest sterical alterations on the slippage kinetics of CB[6] along a polyaminated axle.
  • To elucidate the molecular mechanism governing CB[6] threading and slippage.

Main Methods:

  • In silico (computational) experiments were employed.
  • Molecular dynamics simulations were performed to model the slippage process.

Main Results:

  • Slippage kinetics are highly sensitive to minor steric changes in the guest molecule.
  • A plausible threading mechanism involves sequential deprotonation, tunneling as neutral amines, and reprotonation.

Conclusions:

  • The steric profile of guests is a critical determinant of CB[6] dynamic behavior.
  • Understanding the amine deprotonation-tunneling-reprotonation mechanism provides insights into host-guest complex dynamics.