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Exemestane-induced corneal epithelial changes.

Miltiadis Papathanassiou1, Eleni Nikita, Panagiotis Theodossiadis

  • 1Department of Ophthalmology, Attikon University Hospital, Athens, Greece. mpapathanassiou@gmail.com

Cutaneous and Ocular Toxicology
|May 18, 2010
PubMed
Summary
This summary is machine-generated.

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Exemestane, a breast cancer drug, may cause ocular side effects like corneal microcysts. This case report details these changes, which persisted without affecting vision in a 55-year-old woman.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Exemestane is a selective steroidal aromatase inhibitor used in breast cancer treatment.
  • Ocular side effects of exemestane are not well-documented.
  • Corneal changes can impact visual function and quality of life.

Observation:

  • A 55-year-old woman developed bilateral corneal gray-white bands.
  • These changes presented as intraepithelial microcysts during a routine eye examination.
  • The patient was undergoing treatment with exemestane for breast cancer.

Findings:

  • The corneal epithelial changes persisted for 1 year of follow-up.
  • Visual acuity remained unaffected despite the observed corneal microcysts.
  • A potential causal link between exemestane and these corneal cysts was suggested.

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Implications:

  • This case highlights a potential ocular toxicity associated with exemestane.
  • Ophthalmologists should be aware of these possible side effects in patients on exemestane.
  • Further research may be needed to understand the mechanism and prevalence of exemestane-induced corneal changes.