Anesthesia induction, emergence, and postoperative behaviors in children with attention-deficit/hyperactivity

Alan R Tait1, Terri Voepel-Lewis, Constance Burke

  • 1Department of Anesthesiology, University of Michigan Health System, Ann Arbor, MI 48109, USA. atait@umich.edu

Insights

Children with attention-deficit/hyperactivity disorder (ADHD) experienced more difficulties during anesthesia induction and showed increased postoperative behavioral issues compared to their peers. These findings highlight the need for tailored care in pediatric anesthesia.

Area of Science:

  • Pediatric Anesthesiology
  • Neurodevelopmental Disorders
  • Behavioral Science

Background:

  • Increasing prevalence of attention-deficit/hyperactivity disorder (ADHD) in pediatric populations.
  • Anesthesiologists encounter more children with ADHD undergoing surgical procedures.
  • Need for understanding perioperative behavioral differences in children with ADHD.

Purpose of the Study:

  • To prospectively compare anesthesia induction, emergence, and postoperative behaviors in children with and without ADHD.
  • To identify specific behavioral challenges faced by children with ADHD during the perioperative period.
  • To inform clinical practice regarding the anesthetic management of children with ADHD.

Main Methods:

  • Prospective, observational study design.
  • Inclusion of 268 children aged 4-17 years with confirmed ADHD undergoing elective surgery.
  • Matched control group of children without ADHD.
  • Use of established scales for preoperative, induction, and emergence behaviors.
  • Modified Post-Hospital Behavioral Questionnaire for postoperative behaviors via telephone.

Main Results:

  • Children with ADHD demonstrated significantly less cooperation during anesthesia induction (20.9% vs 10.6%, P=0.001).
  • Children with ADHD exhibited significantly greater postoperative maladaptive behaviors compared to controls.
  • Specific postoperative issues in children with ADHD included concentration difficulties, disobedience, impulsivity, poor appetite, and increased temper tantrums.

Conclusions:

  • This is the first prospective study to examine perioperative and postoperative behaviors in children with ADHD.
  • Results alert anesthesiologists to potential induction difficulties.
  • Findings emphasize the likelihood of postoperative behavioral problems at home and school for children with ADHD.
Abstract

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.