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Updated: Jun 13, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
[Thrombolytic therapy after intraventricular haemorrhage]
Karsten Hølledig Gadegaard1, Bent Lob Dahl, Torben Skovbo Hansen
1Anaestesiologisk Afdeling, Arhus Sygehus, Arhus Universitetshospital, DK-8000 Arhus C, Denmark. karsgade@rm.dk
Ugeskrift for Laeger
|May 18, 2010
Summary
Intraventricular haemorrhage (IVH) can be fatal. A novel treatment using rt-PA through an external drain successfully cleared brain bleeds, leading to good patient recovery.
Area of Science:
- Neurology
- Neurosurgery
- Pharmacology
Background:
- Intraventricular haemorrhage (IVH) presents significant mortality risks.
- Current treatments focus on intracranial pressure management and external ventricular drainage.
- Subarachnoid haemorrhage can lead to obstructive hydrocephalus and IVH.
Observation:
- A 53-year-old female presented with massive IVH and hydrocephalus secondary to subarachnoid haemorrhage.
- The patient underwent treatment with recombinant tissue plasminogen activator (rt-PA) delivered via an external drain.
Findings:
- The rt-PA administration facilitated effective lysis of intraventricular blood clots.
- Complete clearance of the ventricular system from blood was achieved within days.
- The patient experienced a favorable neurological recovery post-treatment.
Implications:
- This case suggests rt-PA is a viable option for IVH clot lysis.
- Intraventricular thrombolysis may improve outcomes in patients with severe IVH.
- Further research into rt-PA for IVH is warranted to establish efficacy and safety.
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