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Published on: April 4, 2018
Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole
Chi-Un Pae1, Alberto Chiesa, Alessandro Serretti
1Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon, Kyonggi-Do, Republic of Korea. pae@catholic.ac.kr
Abstract:
We investigated possible influences of 3 single nucleotide polymorphisms in the d-amino acid oxidase activator (rs2391191, rs947267, rs3918342) on clinical outcomes and side effects in 86 Korean schizophrenia patients treated with aripiprazole for 8weeks, finding that individuals carrying rs2391191 A allele had significantly lower brief psychiatric rating scale scores than subjects carrying the G allele at each time point. Further research is needed to determine the role of DAOA on the response to antipsychotics.
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