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Published on: April 1, 2019
5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder
Dubravka Hranilovic1, Sofia Blazevic, Marina Babic
1Department of Animal Physiology, Faculty of Science, University of Zagreb, and Psychiatric Hospital for Children and Youth, Zagreb, Croatia. dubravka@zg.biol.pmf.hr
Abstract:
Disturbances in the expression/function of the 5-HT2A receptor are implicated in autism. The association of the 5-HT2A receptor gene with autism was studied in the Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism.
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