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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Comparison of structure-dependent hormetic cytotoxicity induced by coplanar and non-coplanar PCB congeners
Yingxu Chen1, Kaili Shen, Chaofeng Shen
1Ministry of Agriculture Key Laboratory of Non-point Source Pollution Control, Institute of Environmental Science and Technology, Zhejiang University, Hangzhou 310029, China. yxchen@zju.edu.cn
Abstract:
The effect of polychlorinated biphenyls (PCBs) on Vero cell proliferation was investigated, with the attempts to assess the possible hormetic dose-response and to compare their structure-dependent toxicity. Both PCB congeners revealed low doses stimulation in our experiment. However, significant cytotoxicity was only observed in PCB 52 concentrations larger than 0.1 microg ml(-1), while there was no significant inhibition in PCB 77-treated cells at concentrations selected. Furthermore, the time-dependent cytotoxic trends were different. The comparison between PCB 52 and PCB 77 indicated that the cytotoxic mechanisms involved in coplanar or non-coplanar PCB congener exposure were different, and this difference might be associated with individual genotoxicity and the release of contact inhibition, respectively.
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