Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology.

Journal of neuroinflammation·2026

Same author

Non-compacted, PET-insensitive amyloid states increase after systemic inflammation and predict neuritic damage across Aβ pathology models and Alzheimer patients.

Research square·2026

Same author

Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology.

Nature·2025

Same author

Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn.

Cells·2025

Same author

Diversity of Aβ aggregates produced in a gut-based Drosophila model of Alzheimer's disease.

PloS one·2025

Same author

Spatial in situ mapping of cellulose and other biopolymers reveals the 3D tissue architecture in the green algae Ulva fenestrata.

International journal of biological macromolecules·2025

Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019

Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019

Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Conjugated polymers for enhanced bioimaging.

Therése Klingstedt¹, K Peter R Nilsson

¹Department of Chemistry, IFM, Linköping University, Sweden.

Biochimica Et Biophysica Acta

|May 18, 2010

Summary

This summary is machine-generated.

Conjugated polymers offer sensitive bioimaging and biosensing capabilities for detecting DNA and protein conformational changes. These novel molecular tools aid in characterizing diseases like Alzheimer's and studying biological events.

More Related Videos

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

Related Experiment Videos

Last Updated: Jun 13, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Optical Control of Living Cells Electrical Activity by Conjugated Polymers

Published on: January 28, 2016

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

Area of Science:

Nanotechnologies
Biomedicine
Molecular Imaging

Background:

Conjugated polymers (CPs) serve as bioimaging tools and biosensors, linking spectral signals to biological processes.
Detection relies on light harvesting or conformation-sensitive optical properties of CPs.
Biomolecules or events are detected via FRET or conformational changes impacting CP optical properties.

Purpose of the Study:

Review the use of CPs for sensitive detection of DNA and protein conformational changes.
Focus on CP binding to protein deposits in diseases like Alzheimer's disease (AD).
Discuss the potential of tailor-made CPs for in vivo optical imaging of protein aggregates.

Main Methods:

Utilizing fluorescence resonance energy transfer (FRET) for detection.
Analyzing conformational changes in conjugated polymer backbones.
Developing specific CP binding to protein aggregates.

Main Results:

CPs demonstrate sensitive detection of genetic material.
CPs enable characterization of pathological hallmarks in protein misfolding disorders.
Tailor-made CPs show promise for in vivo imaging of protein aggregates.

Conclusions:

Unique optical properties of CPs make them valuable molecular tools.
CPs facilitate sensitive bioimaging of biological processes.
CPs offer a complementary approach to conventional techniques for studying biological events.