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[Gastroduodenal pathology in pyelonephritis in children]
Insights
Children with pyelonephritis often have upper digestive tract issues, including Campylobacter pylori infection. Treatment should address both pyelonephritis and gastroduodenal pathology for better outcomes.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Nephrology
Background:
- Pyelonephritis, a kidney infection, can be associated with gastrointestinal complications in children.
- Upper alimentary tract lesions are frequently observed in pediatric patients with urinary tract infections.
Purpose of the Study:
- To investigate the prevalence and nature of upper alimentary tract lesions in children diagnosed with pyelonephritis.
- To identify specific pathologies, such as Campylobacter pylori infection, co-occurring with pyelonephritis in pediatric patients.
Main Methods:
- Intragastric pH-metry was performed on 91 children (aged 4-15) with pyelonephritis.
- Endoscopic examination and histological analysis of gastric and duodenal biopsy specimens were conducted.
- Campylobacter pylori presence was assessed in antral biopsy samples.
Main Results:
- Gastroduodenal pathology was diagnosed in three-quarters of the children studied.
- Campylobacter pylori was identified in the gastric antrum mucosa of 69.4% of these children.
- A significant association between pyelonephritis and upper digestive tract pathology, including H. pylori, was observed.
Conclusions:
- Children with pyelonephritis exhibit a high incidence of gastroduodenal pathology, frequently involving Campylobacter pylori.
- Integrated treatment strategies are necessary, addressing both pyelonephritis and upper alimentary tract conditions, including H. pylori eradication.
- Dietary modifications and anti-inflammatory agents are recommended alongside specific treatments for H. pylori.
Abstract:
The authors describe lesions of the upper alimentary tract in 91 children aged 4 to 15 years suffering from pyelonephritis. Intragastric pH-metry, endoscopy and histological examination of biopsy specimens from the gastric and duodenal mucosa were carried out, as a result of which gastroduodenal pathology was diagnosed in 3/4 of the patients. In 69.4% of the children, biopsy specimens of the mucous membrane of the antrum of the stomach showed Campylobacter pylori. Such combined pathology requires, in addition to the treatment of pyelonephritis correction of the diet, administration of agents that may contribute to the decrease of upper alimentary tract inflammation. If Campylobacter pylori are detected, the treatment eliminating those bacteria is to be administered.