Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

No Evidence for Depletion of Circulating Lymphocyte Populations in Primary Brain Tumor Patients Receiving Radiation Therapy Alone.

International journal of radiation oncology, biology, physics·2026

Same author

Evaluation of the ESMO-magnitude of clinical benefit scale version 2.0 for the definitive treatment of HPV positive oropharynx cancer with radiation therapy.

Oral oncology·2026

Same author

Monte Carlo in radiation therapy as physics in medicine & biology marks its seventieth anniversary.

Physics in medicine and biology·2026

Same author

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Physics in medicine and biology·2026

Same author

PRISM: An open-source framework for regularized material decomposition on a novel kV dual-layer imager.

Medical physics·2026

Same author

Diagnostic Agreement and Prognostic Value of Clinically Interpreted CT vs MRI for Incidentally Discovered Covert Cerebrovascular Disease.

Neurology·2026

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

In vivo proton beam range verification using spine MRI changes.

Michael F Gensheimer¹, Torunn I Yock, Norbert J Liebsch

¹Vanderbilt University School of Medicine, Nashville, TN 02114, USA.

International Journal of Radiation Oncology, Biology, Physics

|May 18, 2010

Summary

Quantitative magnetic resonance imaging (MRI) changes in vertebral bone marrow can precisely detect the distal dose edge in proton radiation therapy. This in vivo method revealed a potential systematic overshoot in some proton spine treatments, aiding treatment accuracy.

More Related Videos

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Quantitative [¹⁸F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Published on: November 14, 2017

Related Experiment Videos

Last Updated: Jun 13, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Quantitative [¹⁸F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur

Published on: November 14, 2017

Area of Science:

Medical Physics
Radiotherapy
Quantitative Imaging

Background:

Proton therapy offers dosimetric advantages but faces challenges with distal dose edge uncertainty.
Vertebral bone marrow undergoes fatty replacement post-radiation, detectable via MRI.
This provides an opportunity for in vivo dose distribution assessment.

Purpose of the Study:

To utilize quantitative spine MRI changes for precise detection of the distal dose edge in proton radiation patients.
To assess in vivo proton range accuracy in spine treatments.

Main Methods:

T1-weighted MRI images were registered to planning CT scans from 10 proton spine irradiation patients.
A radiation dose-MRI signal intensity curve was developed using the sacral lateral beam penumbra.
This curve was applied to measure range errors in the lumbar spine.

Main Results:

Increased MRI signal intensity correlated with higher radiation doses (0-37.5 Gy (RBE)) in the lateral penumbra.
Proton beams occasionally penetrated beyond the planned distal edge.
A mean overshoot of 1.9 mm was observed, within the method's inherent uncertainty.

Conclusions:

In vivo proton range verification is feasible using post-treatment spine MRI.
Some proton spine treatments exhibit a systematic overshoot of a few millimeters.
The observed range error remains within planned treatment margins; future work may enable adaptive therapy.