Endometrial advancement after triggering with recombinant or urinary HCG: a randomized controlled pilot study

Area of Science:

• Reproductive Endocrinology
• In Vitro Fertilization (IVF)

Background:

• Luteal endometrial advancement exceeding 3 days is linked to failed IVF pregnancies.
• Final oocyte maturation protocols significantly influence endometrial receptivity.

Purpose of the Study:

• To compare the effects of recombinant human chorionic gonadotrophin (recHCG) and urinary human chorionic gonadotrophin (uHCG) on endometrial histology advancement.
• To assess the impact of these agents on endometrial maturation in IVF patients.

Main Methods:

• A randomized study involving 30 patients undergoing IVF.
• Patients received either recHCG or uHCG for final oocyte maturation.
• Endometrial biopsy and histological evaluation using Noyes' criteria were performed.

Main Results:

• Mean endometrial advancement was comparable between recHCG (2.03 days) and uHCG (2.17 days) groups.
• A higher proportion of patients in the recHCG group had less than 3 days' advancement (69% vs. 43%).
• Delivery rates were numerically higher in the recHCG group (38.5% vs. 28.6%), though not statistically significant.

Conclusions:

• Both recHCG and uHCG effectively induce endometrial maturation.
• The potential subtle differences in endometrial advancement and their impact on reproductive outcomes warrant further research.