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Basic principles of pharmacologic action.

¹College of Nursing, University of Illinois, Chicago.

The Nursing Clinics of North America

|June 1, 1991

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Nurses can improve drug therapy outcomes by assessing individual patient factors that influence drug response. Understanding pharmacokinetics and pharmacodynamics helps predict and prevent adverse drug effects.

Area of Science:

Pharmacology
Nursing Practice

Background:

Individual patient variability significantly impacts drug efficacy and safety.
Healthcare teams share responsibility for pharmacologic interventions, with nurses playing a key role due to close patient contact.

Purpose of the Study:

To highlight the critical role of nurses in assessing patient-specific factors influencing drug response.
To emphasize the application of pharmacokinetic and pharmacodynamic principles in nursing assessment to optimize drug therapy.

Main Methods:

Review of pharmacokinetic and pharmacodynamic principles relevant to patient care.
Emphasis on nursing assessment of patient-related factors (e.g., disease, nutrition, genetics, lifestyle).

Main Results:

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Patient-specific factors (disease, nutrition, age, genetics, lifestyle) can alter pharmacokinetic and pharmacodynamic parameters.

Assessing these factors allows for prediction of increased risk for adverse drug effects.

Conclusions:

Applying pharmacokinetic and pharmacodynamic principles to nursing assessment enhances drug therapy outcomes.
Proactive nursing assessment can decrease the incidence of adverse drug effects and improve patient safety.