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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Related Experiment Video

Updated: Jun 13, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Male-only systemic lupus.

Rachna Aggarwal1, Bahram Namjou, Shibo Li

  • 1Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Rachna-aggarwal@omrf.ouhsc.edu.

The Journal of Rheumatology
|May 18, 2010
PubMed
Summary
This summary is machine-generated.

Genetic factors may predispose males to systemic lupus erythematosus (SLE). Women in all-male SLE families showed increased autoantibodies, suggesting sex-specific genetic susceptibility in SLE.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Genetics
  • Immunology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) predominantly affects women (10:1 ratio).
  • Familial clustering of SLE suggests a genetic component.
  • Understanding familial SLE patterns is crucial for identifying disease mechanisms.

Purpose of the Study:

  • To investigate familial male SLE within a large cohort.
  • To identify potential sex-specific genetic factors in SLE inheritance.

Main Methods:

  • Analysis of 523 SLE families from the Lupus Multiplex Registry and Repository.
  • Fluorescent in situ hybridization (FISH) to analyze X and Y chromosomes and the TLR7 gene.
  • Autoantibody testing and clinical data abstraction from medical records.

Main Results:

  • Identified 5 families with exclusively male SLE patients.
  • No Y-chromosome-linked gene equivalent (yaa) found in these families.
  • SLE-unaffected female relatives in all-male families had higher rates of antinuclear antibodies (ANA).
  • White men with SLE were more likely to have offspring with SLE than White women.

Conclusions:

  • Findings suggest genetic susceptibility factors that may act exclusively in males.
  • Positive ANA in female relatives of all-male SLE families indicates potential sex-limited gene expression.
  • Male SLE patients may have a higher likelihood of transmitting SLE susceptibility.