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Intraspinal drug therapy.

J A Paice1, J M Magolan

  • 1Rush University, College of Nursing, Chicago, Illinois.

The Nursing Clinics of North America
|June 1, 1991
PubMed
Summary

Intraspinal drug delivery targets spinal cord receptors for enhanced efficacy. This method, including intrathecal baclofen, offers significant benefits for patients unresponsive to oral medications, despite higher costs and potential risks.

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Area of Science:

  • Neurology
  • Pharmacology
  • Pain Management

Background:

  • Intraspinal drug delivery bypasses the blood-brain barrier for direct spinal cord targeting.
  • Route selection (epidural vs. intrathecal) depends on therapy goals, chronicity, and delivery systems.
  • Pharmacological properties influence drug choice for intraspinal administration.

Purpose of the Study:

  • To review the principles and applications of intraspinal drug delivery.
  • To highlight the role of nursing in managing intraspinal therapies.
  • To discuss the potential and limitations of intraspinal drug delivery systems.

Main Methods:

  • Review of existing literature on intraspinal drug delivery.
  • Analysis of drug properties and delivery system choices.
  • Discussion of nursing responsibilities in patient care.

Main Results:

  • Intraspinal opiates and anesthetics have been used since the 1970s for various patient populations.
  • Intrathecal baclofen is effective for severe spasticity in multiple sclerosis and spinal cord injury.
  • Delivery systems range from external catheters to implanted ports and pumps.

Conclusions:

  • Intraspinal drug delivery offers significant benefits for patients unresponsive to oral treatments.
  • The simplest, least invasive method should be prioritized, but intraspinal delivery is crucial for select patients.
  • Further research is needed to advance intraspinal drug delivery, with nurses playing a key role.

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