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Related Experiment Videos

Amantadine toxicity presenting with complex ventricular ectopy and hallucinations.

L Pimentel¹, B Hughes

¹Department of Emergency Medicine, Joint Military Medical Command and Brooke Army Medical Center, Fort Sam Houston, Texas.

Pediatric Emergency Care

|April 1, 1991

Summary

Amantadine hydrochloride overdose can cause dangerous heart rhythm problems. Intravenous lidocaine effectively suppressed these ventricular arrhythmias in a case study of an adolescent patient.

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Area of Science:

Pharmacology
Cardiology
Toxicology

Background:

Amantadine hydrochloride is frequently prescribed but has a narrow therapeutic index.
Amantadine toxicity can affect cardiovascular, central nervous, and respiratory systems due to anticholinergic effects.