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Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...

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Related Experiment Video

Updated: Jun 13, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

Corticosteroids for ARDS.

B T Thompson1

  • 1Medical Intensive Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA. tthompson1@partners.org

Minerva Anestesiologica
|May 18, 2010
PubMed
Summary
This summary is machine-generated.

Glucocorticoids are not effective for preventing Acute Respiratory Distress Syndrome (ARDS) and may increase risks. Lower doses for established ARDS may improve lung function and reduce ventilation duration, but long-term effects require further study.

Related Experiment Videos

Last Updated: Jun 13, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

Area of Science:

  • Critical care medicine
  • Immunology
  • Pharmacology

Background:

  • Glucocorticoids play a role in immune modulation during critical illness.
  • The adrenal axis activation is a key anti-inflammatory response to critical illness.

Purpose of the Study:

  • To review the role of glucocorticoids in immune modulation during critical illness.
  • To analyze clinical trials and meta-analyses of glucocorticoid use in early and late Acute Respiratory Distress Syndrome (ARDS).

Main Methods:

  • Review of selected publications, clinical trials, and meta-analyses.
  • Analysis of data on glucocorticoid administration in patients with or at risk for ARDS, and those with established ARDS or pneumonia.

Main Results:

  • High-dose corticosteroids in early ARDS showed a trend towards increased risk of ARDS development and mortality.
  • Meta-analyses of established ARDS/pneumonia suggested a mortality benefit with corticosteroids, but this was not consistently confirmed in randomized trials.
  • Prolonged, lower-dose glucocorticoid administration improved lung function and reduced mechanical ventilation duration.

Conclusions:

  • Short-duration, high-dose glucocorticoid therapy is ineffective and potentially harmful for ARDS prevention.
  • Lower doses of glucocorticoids for persistent ARDS improve lung function and shorten mechanical ventilation duration.
  • Further trials are necessary to ascertain the impact of corticosteroids on long-term mortality and clinical outcomes in unresolved ARDS.