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Updated: Jun 13, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Influenza A (H1N1) encephalitis with severe intracranial hypertension
1NeuroIntensive Care Unit, San Gerardo Hospital, Monza, Italy. g.citerio@hsgerardo.org
Insights
The 2009 H1N1 influenza virus can cause encephalitis in children, similar to other flu viruses. Early detection and monitoring are crucial for managing this serious neurological complication.
Area of Science:
- Virology
- Neurology
- Pediatrics
Background:
- The 2009 H1N1 influenza A virus pandemic highlighted the potential for novel influenza strains to cause severe illness.
- Influenza virus infections are typically associated with respiratory symptoms, but neurological complications can occur.
Observation:
- This report details a case of encephalitis in a young child diagnosed as a complication of H1N1 virus infection.
- The child presented with symptoms suggestive of influenza-like illness and subsequent neurological deterioration.
Findings:
- Influenza A virus, specifically the H1N1 strain, can be a direct cause of encephalitis.
- The case underscores that influenza can manifest with severe neurological symptoms beyond typical respiratory illness.
Implications:
- Pediatricians and clinicians should maintain a high index of suspicion for H1N1-associated encephalitis in children with influenza-like illness and altered mental status or seizures.
- Prompt neurological monitoring, including EEG and intracranial pressure management, is vital for mitigating severe outcomes in these patients.
Abstract:
The swine-origin influenza A (H1N1) virus was responsible for the pandemic infection in 2009. We report a case of encephalitis diagnosed as the H1N1 virus infection in a young child. The H1N1 virus infection can be causative of the encephalitis, as with other influenza virus infections. For patients presenting with influenza-like illness accompanied by mental status changes or seizures, high suspicion for unusual presentations of influenza A virus infection and careful monitoring, including EEG and intracranial pressure monitoring, are essential for reducing complications.
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