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Updated: Jun 13, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Surgery for Lone Atrial Fibrillation: Present State-of-the-Art
Jeanne Shen1, Marci Bailey, Ralph J Damiano
1Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO USA.
Insights
The Cox-Maze procedure evolved from complex open-heart surgery to less invasive techniques for atrial fibrillation (AF). Future surgical AF treatments aim for personalized, minimally invasive approaches.
Area of Science:
- Cardiovascular Surgery
- Cardiac Electrophysiology
Background:
- The Cox-Maze III procedure was the established surgical treatment for atrial fibrillation (AF).
- Its complexity limited widespread adoption.
- Advancements in ablation technology have driven the evolution of AF surgical treatments.
Purpose of the Study:
- To review the current state of surgical treatments for lone atrial fibrillation.
- To discuss future directions in minimally invasive AF ablation.
- To highlight the potential for personalized surgical approaches.
Main Methods:
- Review of the evolution from Cox-Maze III to Cox-Maze IV procedures.
- Discussion of minimally invasive techniques and beating heart ablation.
- Exploration of advancements in AF mechanism understanding and diagnostic technologies.
Main Results:
- The development of less invasive surgical options for atrial fibrillation.
- Progress towards performing ablation on a beating heart without cardiopulmonary bypass.
- Identification of future research directions for tailored AF treatments.
Conclusions:
- Surgical treatment for lone AF is moving towards minimally invasive, patient-specific strategies.
- Further understanding of AF mechanisms and improved diagnostics will enable personalized lesion sets.
- The goal is to make effective surgical AF treatment accessible to more patients.
Abstract:
For two decades, the cut-and-sew Cox-Maze III procedure was the gold standard for the surgical treatment of atrial fibrillation (AF), and proved to be effective at curing lone AF and preventing its most dreaded complication, stroke. However, this procedure was not widely adopted due to its complexity and technical difficulty. Over the last 5-10 years, the introduction of new ablation technology has led to the development of the Cox-Maze IV procedure, as well as, more limited lesion sets, with the ultimate goal of performing a minimally-invasive lesion set on the beating heart, without the need for cardiopulmonary bypass. This review summarizes the current state of the art and future directions in the surgical treatment of lone atrial fibrillation. The hope is that as we learn more about the mechanisms of AF and develop preoperative diagnostic technologies capable of precisely locating the areas responsible for AF, it will become possible to tailor specific lesion sets and ablation modalities to individual patients, making the surgical treatment of lone AF available to a larger population of patients.
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