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Related Experiment Video

Updated: Jun 13, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

Increased sleep pressure reduces resting state functional connectivity.

Philipp G Sämann¹, Carolin Tully, Victor I Spoormaker

¹Max Planck Institute of Psychiatry, Neuroimaging Research Group, Kraepelinstr. 2-10, 80804, Munich, Germany. saemann@mpipsykl.mpg.de

Magma (New York, N.Y.)

|May 18, 2010

Summary

This summary is machine-generated.

Partial sleep deprivation (PSD) reduces functional connectivity in the default mode network (DMN) and anticorrelated network (ACN). This finding highlights how sleep pressure impacts brain networks crucial for awareness.

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Area of Science:

Neuroscience
Cognitive Neuroscience
Sleep Research

Background:

Partial sleep deprivation (PSD) impairs human cognition and affective processing.
The default mode network (DMN) and anticorrelated network (ACN) are critical for internally and externally directed awareness.
Previous studies using task fMRI show altered DMN and ACN activation after sleep deprivation.

Purpose of the Study:

To investigate if resting-state fMRI can detect the effects of PSD on the DMN and ACN.
To assess changes in functional connectivity within and between the DMN and ACN following PSD.

Main Methods:

16 healthy volunteers underwent resting-state fMRI (6-minute echoplanar imaging) after normal sleep and after PSD.
Independent component and cross-correlation analyses were used to examine functional connectivity (fc).
Focus was placed on the DMN and ACN.

Main Results:

PSD led to reduced auto-correlation strength in key nodes of the DMN and ACN.
Cross-correlation analysis revealed decreased cortico-cortical connectivity within and between these networks.
These changes indicate altered functional connectivity in the DMN and ACN after sleep deprivation.

Conclusions:

Increased sleep pressure, induced by PSD, is associated with reduced functional connectivity in the DMN and ACN during rest.
These findings help explain cognitive and perceptual alterations observed after sleep deprivation.
The results are relevant for understanding brain function in conditions with increased sleep propensity.