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Effect of Shenmai Injection on ventricular diastolic function in patients with chronic heart failure: An assessment
Rong-guo Ma1, Chun-xia Wang, Yin-hua Shen
1Department of Internal Medicine, The Second People's Hospital of Yuhang District, Hangzhou (311121), China. grm000@126.com
Insights
Shenmai Injection (SMI) effectively improved left ventricular diastolic function (LVDF) in chronic heart failure (CHF) patients. Tissue Doppler imaging (TDI) showed significant positive changes in mitral ring velocities after SMI treatment.
Area of Science:
- Cardiology
- Pharmacology
- Medical Imaging
Background:
- Chronic heart failure (CHF) significantly impairs left ventricular diastolic function (LVDF).
- Effective therapeutic strategies to improve LVDF in CHF patients are crucial.
Purpose of the Study:
- To evaluate the impact of Shenmai Injection (SMI) on LVDF in CHF patients.
- To utilize tissue Doppler imaging (TDI) for assessing these functional changes.
Main Methods:
- A randomized controlled trial involving 64 CHF patients.
- Patients received standard treatment, with the observation group also receiving SMI for 14 days.
- Tissue Doppler imaging (TDI) measured mitral ring velocities (Ea, Aa) pre- and post-treatment.
Main Results:
- The SMI group showed significant improvements in Ea and Ea/Aa, with a decrease in Aa (P<0.05).
- The control group exhibited minor, non-significant changes in these parameters.
- No significant inter-group differences were observed post-treatment, despite intra-group improvements in the SMI group.
Conclusions:
- Shenmai Injection (SMI) demonstrates a positive effect on improving left ventricular diastolic function in patients with chronic heart failure.
- TDI is a valuable tool for assessing the functional improvements in LVDF following SMI treatment.
Objective:
To assess the effect of Shenmai Injection (SMI) on left ventricular diastolic function (LVDF) in patients with chronic heart failure (CHF) by tissue Doppler imaging (TDI).
Methods:
Sixty-four CHF patients were randomly assigned to two groups, the observation group and the control group. Basic treatment including polarized liquid therapy was given to all the patients. In addition, SMI was given to patients of the observation group. The treatment duration was 14 days. TDI was performed in all the patients 3 days prior to the initiation of the treatment and one week after the medication to measure the average movement velocity of the mitral ring of the left ventricle at the early systolic stage and late diastolic stage (Ea and Aa); the outcomes were compared with the corresponding parameters obtained from blood flow Doppler echocardiography, namely, the velocity of the E-wave (E) and A-wave (A).
Results:
After treatment, Ea and Ea/Aa increased and Aa decreased significantly in the observation group (P<0.05). In the control group, although some improvement was seen, there was no statistically significant change (P>0.05). No statistical significance was shown between groups in these parameters after treatment.
Conclusion:
TDI assessment shows that SMI could effectively improve the LVDF in CHF patients.
