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Updated: Jun 13, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
Published on: October 26, 2014
[Surgical pathology of epilepsy]
José Ignacio López1, Iñigo Pomposo-Gaztelu
1Servicio de Anatomía Patológica, Hospital Universitario de Cruces, Universidad del País Vasco, Baracaldo, Vizcaya, España. joseignacio.lopez@osakidetza.net
Introduction:
The surgical treatment of refractory epilepsy represents a large step forward in the quality of life and survival of many patients, particularly for those whose pathology is located in the temporal lobe.
Aim:
To concentrate the basic histological aspects of an extremely varied, although generally little known, genuinely neural pathology into one single review work.
Development:
The causes of refractory epilepsy with a genuinely neurohistological foundation can be either malformative or neoplastic. The former include cortical dysplasias and hippocampal sclerosis, while the latter involve the so-called glioneuronal tumours (dysembryoplastic neuroepithelial tumour, ganglioglioma) and some glial cell-related tumours.
Conclusions:
There is a group of disorders that are intrinsic to cerebral development and primary brain tumours which are closely related to epilepsy. Surgery applied to these processes cures epilepsy in a high percentage of cases that are resistant to pharmacological treatment.
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